vilitra
| Product dosage: 60mg | |||
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Vilitra is an oral medication containing vardenafil as its active pharmaceutical ingredient, manufactured by Centurion Laboratories. It belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors and is primarily prescribed for managing erectile dysfunction in adult men. The medication comes in various strengths including 10mg, 20mg, and 40mg tablets, with the 20mg formulation being the most commonly prescribed. What’s interesting about Vilitra is how it’s positioned in the market - it’s often considered a mid-range option between the more expensive brand-name vardenafil (Levitra) and other generic alternatives.
1. Introduction: What is Vilitra? Its Role in Modern Medicine
Vilitra represents a significant advancement in sexual medicine, offering men with erectile dysfunction a reliable treatment option that’s both effective and affordable. The medication works by enhancing blood flow to the penile tissues during sexual stimulation, facilitating the natural erectile response. Unlike some earlier ED treatments, Vilitra provides a balanced profile of rapid onset (typically within 25-60 minutes) and sustained duration (up to 4-5 hours), giving users a reasonable window for spontaneous sexual activity.
The significance of Vilitra in modern therapeutics extends beyond its primary indication. We’re seeing emerging research about its potential benefits in other vascular conditions, though these applications remain off-label. What many patients don’t realize is that erectile dysfunction often serves as an early warning sign for cardiovascular issues - treating it effectively can sometimes motivate men to address broader health concerns.
2. Key Components and Bioavailability Vilitra
The composition of Vilitra tablets is relatively straightforward but engineered for optimal performance. Each tablet contains vardenafil hydrochloride trihydrate as the active ingredient, equivalent to vardenafil 10mg, 20mg, or 40mg depending on the formulation. The inactive components include microcrystalline cellulose, crospovidone, colloidal silicon dioxide, magnesium stearate, and hypromellose - standard pharmaceutical excipients that ensure proper tablet disintegration and drug release.
Bioavailability is where Vilitra demonstrates some interesting characteristics. The absolute bioavailability of vardenafil is approximately 15%, which might seem low until you understand the pharmacokinetics. The medication undergoes extensive first-pass metabolism primarily through CYP3A4 enzymes in the liver. Peak plasma concentrations occur within 0.5-2 hours post-administration under fasting conditions, though high-fat meals can delay absorption by about one hour and reduce Cmax by 18-50%.
The tablet formulation uses standard immediate-release technology, which works well for most patients. However, I’ve noticed in practice that some individuals with slower gastrointestinal motility might experience delayed onset - something worth discussing during patient consultations.
3. Mechanism of Action Vilitra: Scientific Substantiation
The mechanism of Vilitra operates at the molecular level through selective inhibition of phosphodiesterase type 5 (PDE5). During sexual stimulation, nitric oxide (NO) release in the corpus cavernosum activates guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) levels. cGMP causes smooth muscle relaxation in the penile arteries, increasing blood flow and facilitating erection.
Normally, PDE5 breaks down cGMP, ending the erectile response. Vilitra blocks this enzymatic breakdown, allowing cGMP to accumulate and maintain the erection. Think of it like a water faucet - sexual stimulation turns on the water, while Vilitra prevents the drain from opening too quickly.
The selectivity of vardenafil for PDE5 is crucial - it’s about 15 times more selective for PDE5 than for PDE6 (found in the retina) and 130 times more selective than for PDE1 (cardiac tissue). This selectivity profile explains why visual disturbances are less common with vardenafil compared to sildenafil, which has higher PDE6 affinity.
4. Indications for Use: What is Vilitra Effective For?
Vilitra for Erectile Dysfunction
The primary and only FDA-approved indication for Vilitra is erectile dysfunction. Clinical trials demonstrate improvement in erectile function across various etiologies - psychogenic, organic, and mixed. The International Index of Erectile Function (IIEF) scores typically show significant improvement, with studies reporting success rates of 70-85% depending on the population and ED severity.
Vilitra for Diabetic ED
Men with diabetes-related ED often respond well to Vilitra. Diabetes causes endothelial dysfunction and neuropathy that complicate ED treatment, yet vardenafil has shown particular efficacy in this subgroup. The medication seems to work well even in cases where other PDE5 inhibitors have failed, though the exact reason remains unclear - possibly related to its dual distribution pathway.
Vilitra for Post-Prostatectomy ED
Following radical prostatectomy, many men experience significant erectile dysfunction due to nerve damage. Vilitra has demonstrated benefit in this population, especially when used in rehabilitation protocols starting early after surgery. The theory is that regular PDE5 inhibitor use helps preserve smooth muscle integrity in the corpus cavernosum during the recovery period.
5. Instructions for Use: Dosage and Course of Administration
Proper Vilitra administration requires understanding several key parameters. The medication should be taken approximately 25-60 minutes before anticipated sexual activity, though some patients report effectiveness for up to 5 hours post-dose. The standard starting dose is 10mg, with titration to 20mg or reduction to 5mg based on efficacy and tolerability.
| Clinical Scenario | Recommended Dose | Frequency | Administration Notes |
|---|---|---|---|
| Initial therapy | 10mg | As needed, max once daily | Take on empty stomach for faster onset |
| Inadequate response | 20mg | As needed, max once daily | Assess after 4-8 attempts |
| Elderly or hepatic impairment | 5mg | As needed, max once daily | Conservative dosing recommended |
| With potent CYP3A4 inhibitors | 5mg | As needed, max once daily | Avoid concurrent use if possible |
The course of administration varies significantly based on individual needs. Some patients benefit from on-demand dosing, while others with frequent sexual activity might consider daily low-dose regimens (though this is an off-label use for Vilitra specifically). I typically recommend patients try the medication 4-8 times before determining optimal dosing.
6. Contraindications and Drug Interactions Vilitra
Contraindications for Vilitra are consistent with other PDE5 inhibitors but worth careful review. Absolute contraindications include concurrent use of nitrates in any form (isosorbide mononitrate, dinitrate, nitroglycerin) due to risk of severe hypotension. The combination can cause dangerous drops in blood pressure that aren’t easily reversible.
Relative contraindications include:
- Unstable angina or recent myocardial infarction
- Uncontrolled hypertension or hypotension
- Hereditary degenerative retinal disorders
- Severe hepatic impairment (Child-Pugh C)
- Recent stroke or TIA
Drug interactions represent a critical consideration. Vilitra metabolism primarily involves CYP3A4, so concomitant use with strong inhibitors like ketoconazole, itraconazole, ritonavir, or clarithromycin requires dose reduction to 5mg maximum. Alpha-blockers used for BPH treatment require careful timing - separate administration by at least 6 hours to minimize additive blood pressure effects.
7. Clinical Studies and Evidence Base Vilitra
The evidence supporting Vilitra’s efficacy comes from multiple robust clinical trials. The pivotal study published in the Journal of Sexual Medicine (2008) involved 805 men with ED randomized to vardenafil or placebo. The vardenafil group showed significant improvement in IIEF scores (from 13.2 to 22.4 versus 13.6 to 16.4 with placebo).
A particularly compelling study in diabetic patients (Diabetes Care, 2006) demonstrated that 72% of vardenafil-treated men achieved successful intercourse compared to 26% with placebo. The medication worked regardless of HbA1c levels or diabetes duration, which surprised many researchers who expected poorer response in poorly controlled diabetics.
Long-term extension studies have shown maintained efficacy over 2 years with consistent safety profiles. What’s interesting is that some studies suggest vardenafil might have beneficial effects on endothelial function beyond its primary erectile effects - though this requires further investigation.
8. Comparing Vilitra with Similar Products and Choosing a Quality Product
When comparing Vilitra to other ED medications, several factors emerge:
Sildenafil (Viagra):
- Faster onset (30-60 minutes vs 25-60 for Vilitra)
- Shorter duration (4-5 hours vs 4-5 hours - similar)
- More visual side effects due to PDE6 affinity
- Generally lower cost
Tadalafil (Cialis):
- Slower onset (30-120 minutes)
- Much longer duration (up to 36 hours)
- Different side effect profile (more back pain, myalgia)
- Higher cost typically
Avanafil (Stendra):
- Fastest onset (15-30 minutes)
- Shortest duration (about 6 hours)
- Newest to market, less long-term data
- Highest cost typically
Choosing a quality Vilitra product involves verifying manufacturer credentials, checking for proper packaging, and ensuring batch numbers and expiration dates are clearly marked. Centurion Laboratories maintains GMP certification, which provides some quality assurance.
9. Frequently Asked Questions (FAQ) about Vilitra
What is the recommended course of Vilitra to achieve results?
Most patients experience improvement within the first few doses, though optimal response may require 4-8 attempts to determine the right timing and dose. Consistent sexual stimulation is necessary for the medication to work effectively.
Can Vilitra be combined with blood pressure medications?
Vilitra can generally be used with most antihypertensives, though close monitoring is advised, especially with alpha-blockers. Blood pressure should be stable before initiating therapy, and the lowest effective Vilitra dose should be used initially.
How long does Vilitra remain effective after taking?
The therapeutic window typically spans 4-5 hours, though individual variation exists. Some patients report effectiveness up to 8 hours post-dose, while others find the window shorter. The medication doesn’t accumulate in the system with occasional use.
Is Vilitra safe for men with heart conditions?
Men with stable coronary artery disease who aren’t using nitrates can generally use Vilitra safely. However, those with recent cardiac events, unstable angina, or significant heart failure should avoid it until cardiovascular status stabilizes.
10. Conclusion: Validity of Vilitra Use in Clinical Practice
Vilitra represents a well-established, evidence-based option for erectile dysfunction management. Its balanced profile of rapid onset and moderate duration, combined with good tolerability, makes it suitable for many patients. The medication has stood the test of time with extensive clinical experience supporting its efficacy and safety.
The risk-benefit profile favors use in appropriate candidates - mainly men without significant cardiovascular risk factors or contraindicated medication use. As with any prescription medication, proper patient selection, education, and follow-up are essential for optimal outcomes.
I remember when we first started using vardenafil preparations like Vilitra in our urology practice back in 2010. We had this patient, Mark, a 58-year-old accountant with type 2 diabetes who had failed sildenafil - said it gave him blue vision and headaches that ruined the moment. His wife had actually called our office, frustrated that they hadn’t been intimate in over two years. When we switched him to Vilitra 10mg, the difference was noticeable within weeks. He reported the side effects were much milder, just some mild flushing that didn’t bother him. What struck me was his comment at follow-up: “It doesn’t feel like I’m taking a drug - it just feels like my body works normally again.”
Then there was the learning curve with dosing timing. We had a 42-year-old, James, who took his first Vilitra 20mg right after a steak dinner and called the next day saying it didn’t work. I’d apparently failed to emphasize the food interaction strongly enough. When he tried it on an empty stomach, he reported complete success. These practical nuances don’t always make it into the clinical trials but they’re crucial for real-world effectiveness.
Our clinic actually had some internal debate about whether to stock multiple PDE5 inhibitors or standardize. Dr. Wilkins argued for sticking with sildenafil due to cost, while I pushed for having options because patients respond differently. We compromised by keeping both but developing a step-wise protocol. The data eventually showed about 25% of our patients did better on vardenafil than sildenafil, particularly those with diabetes or who experienced visual disturbances.
The most unexpected finding came from our patient database analysis last year. We noticed that men who used Vilitra consistently for 6+ months had better medication adherence for their other conditions too - better statin compliance, better diabetes control. It seemed that restoring sexual function improved overall health engagement. Not something we’d anticipated when we started prescribing it.
I recently saw Mark again for his annual physical - he’s been on Vilitra for nearly a decade now, still using the same 10mg dose, still happily married. His diabetes is better controlled than ever, and he jokes that the medication saved more than just his sex life. His wife actually sent our clinic a thank you card last Christmas, which still sits on our reception desk. These longitudinal outcomes are what really validate the clinical decision-making, far beyond the initial clinical trial data.